When the mysterious first aid kit takes golden retriever Ranger to New Orleans shortly before Hurricane Katrina hits, he finds himself helping Clare Porter and her grandmother, who are waiting for Clare's father at their home in the Lower Ninth Ward--and when the levees break and Clare is separated from Nana, Ranger must somehow get her to the relative safety of the Superdome, and reunite her with her family.

Twelve-year-old "Li'l T" and his family face great losses caused by Hurricane Katrina, including leaving Buddy, their very special, three-legged dog, behind when they must evacuate.