Leon Kennedy is called in to investigate alongside Pittsburgh PD when a bomb kills a guard at the Carnegie Museum of Art. But when that guard rises from the autopsy table and begins a chain reaction of undead corpses hunting for blood, Leon is once again caught in a complex web of intrigue.

Nineteen years ago, a parasitic fungal outbreak killed the majority of the world's population. In one of the few remaining quarantine zones, thirteen-year-old Ellie begins her new life as a ward of a military boarding school, where a friendship with fellow student Riley leads to her first trip into the outside world. Beyond the walls of the regimented civil order they know, Ellie and Riley are soon confronted with the violent way of life of the insurgent...