The Great Depression has hit West Virginia hard. Men are out of work; women struggle to feed hungry children. Luckily, Nurse Becky Myers has returned to care for them. While she can handle most situations, Becky is still uneasy helping women deliver their babies. For these mothers-to-be, she relies on an experienced midwife, her dear friend Patience Murphy.

"Midwife Clara Perry is accustomed to comforting her pregnant patients, calming fathers-to-be as they anxiously await the birth of their children, and ensuring the babies she delivers come safely into the world. But when Clara's life takes a nosedive, she realizes she hasn't been tending to her own needs and does something drastic: she runs away and starts over again in a place where no one knows her or the mess she's left behind in West Virginia....