When a murderous menace known only as the "Riverdale Ripper" is on the prowl, taking the lives of some of the most well-known and esteemed inhabitants of Riverdale, Jughead becomes public enemy number one as his family's dark legacy comes to light. They are werewolves, with insatiable thirsts for blood.

Teens June, a military prodigy born into wealth, and Day, a criminal from the slums, are brought together and face plague, war, and a powerful, common enemy.